Ther-Biotic® InterFase® Plus combines the same unique enzyme formulation found in Ther-Biotic® InterFase® with ethylenediaminetetraacetic acid (EDTA). The presence of calcium, iron, and magnesium is essential for biofilm creation and serves to cross-link the anionic regions of polymers. Ther-Biotic® InterFase® Plus includes EDTA which binds the metals needed for biofilm formation. Ther-Biotic® InterFase® Plus can be used for maximum antibiofilm activity.